Selected Publications
| Variant reclassification in cancer susceptibility genes and an updated variant spectrum of Turkish breast and colorectal cancer patients Can ND, Akcay IM, Celik E, Ciftci C, Unal B, Agaoglu NB, Doganay HL, Dinler Doganay G. Hum Genomics. 2026 Feb 8;20(1):39. doi: 10.1186/s40246-026-00915-0. PMID: 41656315; PMCID: PMC12918020. |
| X-ray crystallographic and hydrogen deuterium exchange studies confirm alternate kinetic models for homolog insulin monomers Ayan E, Türk M, Tatlı Ö, Bostan S, Telek E, Dingiloğlu B, Doğan BZ, Alp MI, Katı A, Dinler-Doğanay G, Demirci H. PLoS One. 2025 Apr 21;20(4):e0319282. doi: 10.1371/journal.pone.0319282. PMID: 40257998; PMCID: PMC12011231. |
| A BAG-1-inhibitory peptide, GO-Pep, suppresses c-Raf activity in cancer Ayan E, Türk M, Tatlı Ö, Tatli O, Cebi E, Turk M, Dingiloglu B, Sezan A, Basturk E, Temur BZ, Eyupoglu AE, Bicak B, Erdal E, Erman B, Can Ö, Dinler Doganay G. Commun Biol. 2025 Feb 28;8(1):336. doi: 10.1038/s42003-024-07419-4. PMID: 40021821; PMCID: PMC11871328. |
| Bag-1-mediated HSF1 phosphorylation regulates expression of heat shock proteins in breast cancer cells Kizilboga T, Özden C, Can ND, Onay Ucar E, Dinler Doganay G. FEBS Open Bio. 2024 Sep;14(9):1559-1569. doi: 10.1002/2211-5463.13843. Epub 2024 Jul 24. PMID: 39049197; PMCID: PMC11492399. |
| Structural and molecular characterization of collagen-type I extracted from lamb feet A Ata O, Bakar B, Turkoz BK, Kumcuoglu S, Aydogdu Y, Gumustas B, Doganay GD, Basturk E, Tavman S. J Food Sci. 2024 Jan;89(1):330-341. doi: 10.1111/1750-3841.16870. Epub 2023 Dec 5. PMID: 38051022. |
| A two-step purification platform for efficient removal of Fab-related impurities: A case study for Ranibizumab Tatli O, Oz Y, Dingiloglu B, Yalcinkaya D, Basturk E, Korkmaz M, Akbulut L, Hatipoglu D, Kirmacoglu C, Akgun B, Turk K, Pinar O, Sariyar Akbulut B, Atabay Z, Tahir Turanli E, Kazan D, Dinler Doganay G. Heliyon. 2023 Oct 31;9(11):e21001. doi: 10.1016/j.heliyon.2023.e21001. PMID: 38027967; PMCID: PMC10651443. |
| Cryogenic X-ray crystallographic studies of biomacromolecules at Turkish Light Source “Turkish DeLight“ Atalay N, Akcan EK, Gül M, Ayan E, Destan E, Ertem FB, Tokay N, Çakilkaya B, Nergiz Z, Karakadioğlu G, Kepceoğlu A, Yapici İ, Tosun B, Baldir N, Yildirim G, Johnson JA, Güven Ö, Shafiei A, Arslan NE, Yilmaz M, Kulakman C, Paydos SS, Çinal ZS, Şabanoğlu K, Pazarçeviren A, Yilmaz A, Canbay B, Aşci B, Kartal E, Tavli S, Çaliseki M, Göç G, Mermer A, Yeşilay G, Altuntaş S, Tateishi H, Otsuka M, Fujita M, Tekin Ş, Çiftçi H, Durdaği S, Dinler Doğanay G, Karaca E, Kaplan Türköz B, Kabasakal BV, Kati A, Demirci H. Turk J Biol. 2023 Jan 11;47(1):1-13. doi: 10.55730/1300-0152.2637. PMID: 37529114; PMCID: PMC10387866. |
| Altered kidney function induced by SARS-CoV-2 infection and acute kidney damage markers predict survival outcomes of COVID-19 patients: a prospective pilot study Temiz MZ, Hacibey I, Yazar RO, Sevdi MS, Kucuk SH, Alkurt G, Doganay L, Dinler Doganay G, Dincer MM, Yuruk E, Erkalp K, Muslumanoglu AY. Ren Fail. 2022 Dec;44(1):233-240. doi: 10.1080/0886022X.2022.2032743. PMID: 35172674; PMCID: PMC8856025. |
| Structure-based engineering of an antiangiogenic scFv antibody for soluble production in E. coli without loss of activity Denizci Öncü M, Balcıoğlu BK, Özgür B, Öztürk HÜ, Serhatlı M, Işık Ş, Erdağ B, Dinler Doğanay G, Özdemir Bahadır A. Biotechnol Appl Biochem. 2022 Oct;69(5):2122-2137. doi: 10.1002/bab.2273. Epub 2021 Nov 12. PMID: 34694021. |
| COVID-19 PCR test performance on samples stored at ambient temperature Agaoglu NB, Yildiz J, Akgun Dogan O, Kose B, Alkurt G, Kendir Demirkol Y, Irvem A, Doganay L, Dinler Doganay G. J Virol Methods. 2022 Mar;301:114404. doi: 10.1016/j.jviromet.2021.114404. Epub 2021 Dec 16. PMID: 34921841; PMCID: PMC8673954. |
| Determining the accuracy of next generation sequencing based copy number variation analysis in Hereditary Breast and Ovarian Cancer Agaoglu NB, Unal B, Akgun Dogan O, Zolfagharian P, Sharifli P, Karakurt A, Can Senay B, Kizilboga T, Yildiz J, Dinler Doganay G, Doganay L. Expert Rev Mol Diagn. 2022 Feb;22(2):239-246. doi: 10.1080/14737159.2022.2048373. Epub 2022 Mar 10. PMID: 35240897. |
| Recent Developments in Targeting RAS Downstream Effectors for RAS-Driven Cancer Therapy Tatli O, Dinler Doganay G. Molecules. 2021 Dec 14;26(24):7561. doi: 10.3390/molecules26247561. PMID: 34946644; PMCID: PMC8703923. |
| Combined Metabolic Activators Accelerates Recovery in Mild-to-Moderate COVID-19 Altay O, Arif M, Li X, Yang H, Aydın M, Alkurt G, Kim W, Akyol D, Zhang C, Dinler-Doganay G, Turkez H, Shoaie S, Nielsen J, Borén J, Olmuscelik O, Doganay L, Uhlén M, Mardinoglu A. Adv Sci (Weinh). 2021 Sep;8(17):e2101222. doi: 10.1002/advs.202101222. Epub 2021 Jun 28. PMID: 34180141; PMCID: PMC8420376. |
| Interactome analysis of Bag-1 isoforms reveals novel interaction partners in endoplasmic reticulum-associated degradation Can ND, Basturk E, Kizilboga T, Akcay IM, Dingiloglu B, Tatli O, Acar S, Ozfiliz Kilbas P, Elbeyli E, Muratcioglu S, Jannuzzi AT, Gursoy A, Keskin O, Doganay HL, Karademir Yilmaz B, Dinler Doganay G. PLoS One. 2021 Aug 24;16(8):e0256640. doi: 10.1371/journal.pone.0256640. PMID: 34428256; PMCID: PMC8384158. |
| Does sampling saliva increase detection of SARS-CoV-2 by RT-PCR Comparing saliva with oro-nasopharyngeal swabs Dogan OA, Kose B, Agaoglu NB, Yildiz J, Alkurt G, Demirkol YK, Irvem A, Doganay GD, Doganay L. J Virol Methods. 2021 Apr;290:114049. doi: 10.1016/j.jviromet.2020.114049. Epub 2020 Dec 30. PMID: 33387561; PMCID: PMC7833528. |
| Seroprevalence of coronavirus disease 2019 (COVID-19) among health care workers from three pandemic hospitals of Turkey Alkurt G, Murt A, Aydin Z, Tatli O, Agaoglu NB, Irvem A, Aydin M, Karaali R, Gunes M, Yesilyurt B, Turkez H, Mardinoglu A, Doganay M, Basinoglu F, Seyahi N, Dinler Doganay G, Doganay HL. PLoS One. 2021 Mar 3;16(3):e0247865. doi: 10.1371/journal.pone.0247865. PMID: 33657142; PMCID: PMC7928442. |
| Co-Chaperone Bag-1 Plays a Role in the Autophagy-Dependent Cell Survival through Beclin 1 Interaction Turk M, Tatli O, Alkan HF, Ozfiliz Kilbas P, Alkurt G, Dinler Doganay G. Molecules. 2021 Feb 6;26(4):854. doi: 10.3390/molecules26040854. PMID: 33561998; PMCID: PMC7914623. |
| Germline pathogenic variant spectrum in 25 cancer susceptibility genes in Turkish breast and colorectal cancer patients and elderly controls Akcay IM, Celik E, Agaoglu NB, Alkurt G, Kizilboga Akgun T, Yildiz J, Enc F, Kir G, Canbek S, Kilic A, Zemheri E, Ezberci F, Ozcelik M, Dinler Doganay G, Doganay L. Int J Cancer. 2021 Jan 15;148(2):285-295. doi: 10.1002/ijc.33199. Epub 2020 Aug 19. PMID: 32658311. |
| Bag-1 stimulates Bad phosphorylation through activation of Akt and Raf kinases to mediate cell survival in breast cancer Kizilboga T, Baskale EA, Yildiz J, Akcay IM, Zemheri E, Can ND, Ozden C, Demir S, Ezberci F, Dinler-Doganay G. BMC Cancer. 2019 Dec 28;19(1):1254. doi: 10.1186/s12885-019-6477-4. PMID: 31883527; PMCID: PMC6935482. |